Estradiol Basic information
Product Name: Estradiol
Synonyms: 1,3,5-estratriene-3,17-alpha-diol;1,3,5-Estratriene-3,17alpha-diol;17alpha-Oestradiol;3,17alpha-Dihydroxyestra-1,3,5(10)-triene;3,17-alpha-dihydroxyoestra-1,3,5(10)-triene;3,17alpha-Dihydroxyoestra-1,3,5(10)-triene;5(10)-triene-3,17-diol,(17-alpha)-estra-3;epiestradial
CAS: 57-91-0
MF: C18H24O2
MW: 272.39
EINECS: 200-354-8
Product Categories: Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;57-91-0
Mol File: 57-91-0.mol
Estradiol Structure
Estradiol Chemical Properties
Melting point  176-180 °C(lit.)
alpha  D20 +53 to +56° (c = 0.9 in dioxane)
Boiling point  355.44°C (rough estimate)
density  1.0708 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  ethanol: 50 mg/mL, clear, colorless
form  powder
pka 10.27±0.60(Predicted)
color  white with slight yellow
Water Solubility  3.9mg/L(25 ºC)
Merck  14,3704
CAS DataBase Reference 57-91-0(CAS DataBase Reference)
NIST Chemistry Reference Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
EPA Substance Registry System Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)
Safety Information
Hazard Codes  T,Xn
Risk Statements  45-48-40
Safety Statements  53-45-24/25-22
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  KG3750000
F  8-10
HS Code  29372390
MSDS Information
Provider Language
SigmaAldrich English
ALFA English
Estradiol Usage And Synthesis
Chemical Properties White Solid
Uses Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
Definition ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).
Biological Activity Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
Biochem/physiol Actions Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
target Beta Amyloid | Bcl-2/Bax | Caspase | PARP | Estrogen receptor | GABA Receptor | Progestogen receptor
storage Room temperature
Purification Methods 17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.